Ineffective hematopoiesis is the major characteristic of early myelodysplastic syndromes. Its pathophysiology relies on a diversity of mechanisms supported by genetic events that develop in aging hematopoietic stem cells. Deletion and mutations trigger epigenetic modifications. and co-transcriptional and post-transcriptional deregulations of gene expression. https://www.mabelandfoxs.shop/product-category/changing-pad/