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The PDZ protein Canoe/AF-6 links Ras-MAPK, Notch and Wingless/Wnt signaling pathways by directly interacting with Ras, Notch and Dishevelled.

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Over the past few years. it has become increasingly apparent that signal transduction pathways are not merely linear cascades; they are organized into complex signaling networks that require high levels of regulation to generate precise and unique cell responses. However. the underlying regulatory mechanisms by which signaling pathways cross-communicate remain poorly understood. https://www.roneverhart.com/Mike-and-Ike-Italian-Ice-Candy-5-Ounce-Packs-12-Piece-Box/
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